Another potential consequence of lung collapse is the impairment in ventilatory efficiency. This increases lung heterogeneity and thus the driving pressure (DP), i.e the pressure gradient needed to generate a given VT calculated as plateau pressure minus PEEP that scales VT to the size of the functional lung volume. A potential side effect of low-VT is the reduction of the functional volume of the lung manifested as lung collapse. ![]() The currently recommended protective ventilation strategy is limited to the use of a low, more physiologic tidal volume (VT). Protective mechanical ventilation during anesthesia aims at minimizing lung injury and its inflammatory response, and has been associated to a decrease in postoperative pulmonary complications (PPCs). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was funded by the INCLIVA Biomedical Research Institute.Ĭompeting interests: The authors have declared that no competing interests exist. Received: OctoAccepted: ApPublished: May 11, 2017Ĭopyright: © 2017 Ferrando et al. PLoS ONE 12(5):Įditor: Ary Serpa Neto, Hospital Israelita Albert Einstein, BRAZIL ![]() (2017) Open lung approach versus standard protective strategies: Effects on driving pressure and ventilatory efficiency during anesthesia - A pilot, randomized controlled trial. Citation: Ferrando C, Suarez-Sipmann F, Tusman G, León I, Romero E, Gracia E, et al.
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